Fig. 5.
The phospho-dependent modulation of GABAA receptor currents is occluded by inhibition of dynamin. (a and c) Plots of normalized whole-cell GABA-evoked currents as a function of time in cells dialyzed with or without different peptides. Note that the peptide pepβ3 (200 μg/ml), but not the peptide pepβ3-phos (200 μg/ml), increases the GABAAR current (a). Dialysis with the dynamin inhibitory peptide p4 (20 μM) produces a similar enhancement as dialysis with both pepβ3 and p4 peptides (c). (b and d) Cumulative data (mean ± SEM) showing the percentage control of GABAAR current amplitude with or without different peptide dialysis (by using the ratio of GABAAR current amplitude at the 15th min and the first min).