Table 3. Tissue GUS levels after GUS infusion into MPS VII/E540A^Tg mice at different doses and regimens.

Group	Dose mg/kg	Doses, n	Liver	Spleen	Heart	Kidney	Bone	Bone marrow	Muscle	Eye
I	0	3	0.35 ± 0.08	0.41 ± 0.36	0.053 ± 0.030	0.04 ± 0.02	0.39 ± 0.05	—	—	0.019 ± 0.004
			0.2	0.1	0.25	0.03	0.39	—	—	0.39
	0.3	3	13.29 ± 4.15	1.63 ± 0.61	0.36 ± 0.12	0.39 ± 0.15	1.27 ± 0.03	—	—	0.074 ± 0.027
			7.2	0.5	1.72	0.36	1.27	—	—	1.5
	1.0	2	41.88 ± 14.76	4.49 ± 1.63	0.83 ± 0.05	0.64 ± 0.1	3.57 ± 0.56	—	—	0.126 ± 0.025
			22.6	1.5	4.0	0.6	3.6	—	—	2.6
	2.5	2	96.02 ± 5.44	44.38 ± 24.5	2.16 ± 0.09	3.18 ± 1.18	11.78 ± 0.03	—	—	0.166 ± 0.049
			51.9	14.7	10.4	2.9	11.8	—	—	3.4
	5.0	3	211.8 ± 121	63.83 ± 22.3	3.36 ± 1.29	5.47 ± 2.98	8.66 ± 4.75	—	—	0.231 ± 0.024
			114	21.2	16.2	5.1	8.7	—	—	4.7
II	0		0.31 ± 0.02	0.096 ± .016	0.023 ± 0.023	0.06 ± 0.01	—	0.044 ± 0.024	0.024 ± .010	0.056 ± .023
			0.17	0.03	0.1	0.06	—	0.03	0.48	1.1
	1	4	65.1 ± 28.4	19.0 ± 9.7	1.10 ± 0.35	1.71 ± 1.07	—	6.30 ± 2.84	0.64 ± 0.38	0.19 ± .006
			35.2	6.3	5.3	1.58	—	3.91	12.9	3.9
	2	5	108 ± 25.9	132 ± 105	1.78 ± 0.70	3.69 ± 1.14	—	14.34 ± 9.62	0.81 ± 0.43	0.28 ± .08
			58.4	43.9	8.6	3.42	—	8.9	16.4	5.7
	4	5	230 ± 31.3	113 ± 52	4.18 ± 2.09	7.83 ± 1.13	—	46.44 ± 20.51	2.04 ± 1.56	0.60 ± .23
			124	37.5	20.1	7.25	—	28.8	41.2	12.3
IV	20	2	975 ± 442	374 ± 38	11.5 ± 1	20 ± 1.9	—	173 ± 25	2.95 ± 1.16	1.26 ± 0.39
			527	124	55.3	18.5	—	107	60.0	25.8
WtB6	—	4	185 ± 11.9	301 ± 26.6	20.8 ± 12.5	108 ± 7.5	100 ± 18	161 ± 35	4.95 ± 1.80	4.88 ± 0.68

Data are given as means ± SD, with the percentage of wild-type (Wt) values shown in italic type. —, not applicable.