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. 2005 Oct 3;102(41):14759–14764. doi: 10.1073/pnas.0506927102

Fig. 5.

Fig. 5.

Amino acid changes in gp41 HR1 confer resistance to D5-IgG1. Amino acid residues L568 and K574 in gp41 were changed to alanine in the proviral clone R8.HXB2 and virus stocks were produced by transfection. The antiviral potencies of the indicated entry inhibitors against wild-type and mutant viruses were assessed by using a single-cycle infection assay. Fold-change IC50 refers to the IC50 of the test virus divided by the IC50 of the wild-type virus; fold change > 1 indicates resistance, fold change < 1 indicates hypersensitivity.