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In vivo restoration of RBC bioactivity by ENO inhalation in PAH patients. RBC relaxation in PAH patients before and after ENO (A), and individual (B) and mean data from eight patients (C) are shown. RBC-induced vasorelaxation was enhanced by ENO inhalation (70 ppm, 10 min). *, P < 0.05 relative to baseline, which did not differ significantly from normal RBCs.
