Effects of ENO on hemodynamics and oxygenation in PAH patients. Changes in PVR (A), PAP (B), systemic vascular resistance (C), and arterial pO2 (D) in response to inhaled ENO at ≈1.5, 10, or 70 ppm (0.0025%, 0.025%, or 0.125%, 10 min each) are shown. Data represent the mean ± SEM from 5-10 patients. *, significant difference vs. baseline by mixed procedures (in A, B, and D).