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Proposed model for CA4P-mediated angiogenesis inhibition. Preexisting vessels are invested with SMCs protecting endothelial cells against CA4P-induced cell death. Because nascent unstable tumor neovessels are not ensheathed by periendothelial mural cells, CA4P selectively destabilizes neovessels by inducing VE-cadherin disengagement, therefore increasing the antiangiogenic effects of the neutralizing mAb against VE-cadherin without increasing toxicity to the normal vasculature.
