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TLR7 is the likely target of HIV in pDCs. HEK 293 cells expressing human TLR7 (A) or human TLR9 (B) and an NF-κB–luciferase reporter gene were pretreated (black bars) or not (white bars) with lipofectamine and stimulated overnight with HIV-1MN at doses of 600, 300, and 150 ng p24CA Eq/ml, R848, or CpGB ODN. Cells were lysed and assayed for luciferase gene activity. Data are expressed as luciferase activity in relative light units and are representative of 2 independent experiments.
