Fig. 1. Phylogenetic tree analysis reveals three putative orthologous lineages: the Trm7, Spb1 and Mrm2 families. The Mrm2 family is represented by Mrm2p from S.cerevisiae (P53123), FtsJ/RrmJ from E.coli (AAC76211) and other prokaryotic proteins [M.t., Methanobacterium thermoautotrophicum (G69103); M.j., Methanococcus jannaschii (Q58771); A.f., Archaeglobus fulgidus (O28228); R.p., Rickettsia prowazekii (Q9ZE00); N.m., Neisseria meningitidis (AAF41212); P.a., Pseudomonas aeruginosa (AAG08138); H.i., Haemophilus influenzae (P45162)] and eukaryotic proteins [A.t., Arabidopsis thaliana (CAB69851); C.e., Caenorhabditis elegans (O62251); D.m., Drosophila melanogaster (Q9VDT6); H.s., Homo sapiens (AAF22488); C.a., Candida albicans (unfinished sequence from the Stanford Genome Technology Center, SGTC, http://sequence-www.stanford.edu); S.p., Schizosaccharomyces pombe (P78860); and P.f., Plasmodium falciparum 3D7 (unfinished sequence from the P.falciparum Genome Project–PlasmoDB, http://www.plasmodb.org)]. The Spb1 family is represented by Spb1p from S.cerevisiae (CAA42391) and seven other members [A.t., A.thaliana (CAB69851); P.f., P.falciparum (unfinished sequence from the PlasmoDB); N.c., Neurospora crassa (CAB88626); S.p., S.pombe (T37754); C.a., C.albicans (unfinished sequence from the SGTC); C.e., C.elegans (AAF39868); and D.m., D.melanogaster (AAF48557)]. The Trm7 family is represented by Trm7p from S.cerevisiae (CAA85004) and eight other members [P.f., P.falciparum (unfinished sequence from the PlasmoDB); S.p., S.pombe (Z98980); C.a., C.albicans (unfinished sequence from the SGTC); H.s., H.sapiens (HSA005892); C.e., C.elegans (Q22031); A.t., A.thaliana (CAB69851); and D.m.1. and D.m.2., D.melanogaster (AAF55380 and AAF55857)].