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. 2025 Oct 7;13:1607469. doi: 10.3389/fbioe.2025.1607469

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Copyright © 2025 Vassallo, Di Meo, D’Agostino, La Gatta, Cimini, Toro, Iolascon, Mastrogiacomo and Schiraldi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The figure is composed of a line graph illustrating wound closure percentage over time in 2D culture. Three samples are plotted: pCTR (pink circles), HHA/BC (blue squares), and HHA/BC+PRP (fuchsia triangles). Both HHA/BC and HHA/BC+PRP samples show higher wound closure rates compared with pCTR, reaching near 100% closure by 48 hours. Dashed horizontal lines indicate closure thresholds at 40%, 60%, and 80%. The x-axis represents time in hours, and the y-axis represents wound closure percentage. Differences between samples are visually evident across the time course. — Repair area (%) for the untreated cells and the cells treated with HHA/BC and HHA/BC+PRP. The curves are the results of the mean values of four different captured fields of view ±SD.