Table 1. Demographic data, lung function, MCh, and total IgE values in GC-S and GC-R patients.
| Asthma
|
|||
|---|---|---|---|
| Characteristics | GC-S | GC-R | Control |
| Training set | |||
| n | 32 | 21 | 16 |
| Mean age, yr | 45 ± 17 | 55 ± 19 | 34 ± 12 |
| Sex, male/female | 10/22 | 4/17 | 7/9 |
| Forced vital capacity (FVC) | |||
| % predicted | 83 ± 19 | 76 ± 17 | |
| Liters | 3.7 ± 1.1 | 3.0 ± 1.0 | |
| FEV1 | |||
| % predicted | 81 ± 20 | 73 ± 16 | |
| Liters | 3.1 ± 1.0 | 2.1 ± 0.9 | |
| FEV1/FVC ratio | 79 ± 10 | 72 ± 12 | |
| MCh20 (mg/liter) | 3.1 ± 1.4 | 0.6 ± 1.2 | |
| Positive skin tests, % | 51 | 31 | |
| Total IgE, geometric means | 74 units/liter | 37 units/liter | |
| Test set | |||
| n | 32 | 21 | 16 |
| Mean age, yr | 43 ± 17 | 54 ± 18 | 34 ± 12 |
| Sex, male/female | 10/22 | 3/18 | 7/9 |
| FVC | |||
| % predicted | 85 ± 18 | 79 ± 16 | |
| Liters | 3.9 ± 1.0 | 3.4 ± 0.9 | |
| FEV1 | |||
| % predicted | 84 ± 20 | 77 ± 17 | |
| Liters | 3.3 ± 1.0 | 2.3 ± 0.8 | |
| FEV1/FVC ratio | 79 ± 10 | 72 ± 12 | |
| MCh20 (mg/liter) | 3.7 ± 1.3 | 0.8 ± 1.1 | |
| Positive skin tests, % | 58 | 34 | |
| Total IgE, geometric means | 82 units/liter | 40 units/liter | |
| Cohort | |||
| n | 40 | 39 | |
| Mean age, yr | 39 ± 16 | 48 ± 16 | |
| Sex, male/female | 9/31 | 12/27 | |
| FVC | |||
| % predicted | 89 ± 16 | 80 ± 17 | |
| Liters | 4.0 ± 0.9 | 3.3 ± 0.9 | |
| FEV1 | |||
| % predicted | 86 ± 19 | 78 ± 16 | |
| Liters | 3.4 ± 0.9 | 2.5 ± 0.8 | |
| FEV1/FVC ratio | 78 ± 10 | 72 ± 11 | |
| MCh20 (mg/liter) | 4.7 ± 1.3 | 1.8 ± 1.1 | |
| Positive skin tests, % | 56 | 41 | |
| Total IgE, geometric means | 101 units/liter | 69 units/liter | |
The values expressed include the mean ± SD for the training and test sets used in the microarray analysis at baseline and the cohort used in the RT-PCR analysis.