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. 2005 Oct 12;33(18):5763–5770. doi: 10.1093/nar/gki877

Figure 1.

Figure 1

Molecular beacon targeted against the ribozyme core. Hybridization of the molecular beacon MB-P3 (red) with its target separates the dye (red sphere) and DABCYL quencher (black sphere), resulting in increased fluorescence. MB-P3 is complementary to nt 92–106 in the Tetrahymena ribozyme, which corresponds to the 5′ strand of helix P3 (green), part of the central triple helix and the base of P4. The 5′ strand of P3 is released in misfolded intermediates containing the alternative pairing altP3 between J8/7 (blue) and the 3′ half of P3.