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. 2005 Oct 12;33(18):5799–5808. doi: 10.1093/nar/gki885

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Module and domain structure of NRPS. Above (in the middle): one complete NRPS consisting of three modules. Below: enzymatic domains that are contained in a complete module: Cond: condensation domain, Adenyl: adenylation domain (A domain), N-Meth: N-methylation domain (optional, does not appear in all NRPS), PCP: thiolation domain (Peptidyl Carrier Protein domain), Epi: epimerization domain (optional). Other optional domains are heterocyclation, oxidation, reduction and formylation domains. The substrate specificity of the adenylation domain is the subject of this study.