Table 3.
Univariate and multivariate analysis for independent predictors of terlipressin responders
| Clinical parameters | Univariate | Multivariate | ||
|---|---|---|---|---|
| Odd ratio (95%CI) | P-value |
Adjusted Odd ratio (95%CI) |
P-value | |
| APACHE ll > 25 | 0.69 (0.51–0.91) | 0.008 | N/A | |
| SOFA < 12 | 2.13 (1.39–3.23) | < 0.001 | 33.33 (3.45–100.0) | 0.003 |
| Coronary artery disease | 1.64 (0.87–3.09) | 0.040 | N/A | |
| Pneumonia | 1.31 (1.02–1.68) | 0.046 | N/A | |
| Initial serum lactate < 4 mmol/L | 2.17 (1.37–3.45) | < 0.001 | 33.33 (3.12–100.0) | 0.004 |
|
Total dose of catecholamine > 0.25 mcg/kg/min before study druga |
0.28 (0.11–0.75) | N/A | ||
| Adrenaline | 0.68 (0.49–0.96) | < 0.001 | N/A | |
| pH > 7.3 | 1.55 (1.20–2.02) | 0.015 | N/A | |
| HCO3 > 18 mmol/L | 1.36 (0.95–1.95) | 0.001 | N/A | |
| Mechanical ventilator | 0.53 (0.22–1.25) | 0.042 | N/A | |
Abbreviations: APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA sequential organ failure assessment, °C degrees Celsius; mmol/L millimole per liter, mcg/kg/min micrograms per kilogram per minute, N/A not remained in the final multivariate analysis model
a Vasoactive dose or norepinephrine dose equivalents were calculated with the following equation:
Norepinephrine dose equivalent (micrograms per kilogram per minute [mcg/kg/min]) = (norepinephrine [mcg/kg/min] + epinephrine [mcg/kg/min] + dopamine [mcg/kg/min])/100 [18].