Fig. 5. Mean K_ATP conductance recorded from patches excised from oocytes co-expressing Kir6.2 and either wild-type SUR1 or SUR containing mutations in the linker of NBD2 (SUR1-Q1426A and SUR1-H1537A). Currents were recorded in the presence of 100 µM ADP with (white bars) or without (black bars) 2 mM Mg²⁺. The slope conductance (G) is expressed as a fraction of the mean of that obtained in control solution before and after exposure to ADP (Gc). The number of patches is given above the bar.