Skip to main content
. 2025 Oct 8;13:1659880. doi: 10.3389/fcell.2025.1659880

FIGURE 2.

Composite image illustrating various biological data analyses. Panel A shows histological sections labeled NC and PE, highlighting villous region and basal plate. Panels B, C, and D display UMAP plots of data clusters differentiated by color. Panel E presents a heatmap of gene expression with varying intensity. Panel F is a dot plot of KEGG enrichment for pathways, with significance and enrichment score. Panel G features another UMAP for data distribution. Panel H shows a dot plot correlating features with identity, represented by color and dot size.

ST landscape of placental tissue from patients with preeclampsia and NC individuals. (A) H&E staining image of the placental tissue section from one patient with preeclampsia and one NC individual, demonstrating the villous region and the basal plate. (B–D) Unsupervised clustering analysis (UMAP) plots, and ST feature plots of 8 clusters in two placental samples. (E) Heatmap showing the top 5 marker genes of each cluster. (F) KEGG was used for differential gene enrichment analysis between patients with preeclampsia and NC individuals. (G) UMAP showing the definitions of 10 cell types in the placenta, including erythrocytes, EVTs, fibroblasts, macrophages, NK cells, SCTs, T cells, SMCs, VCTs, and pVCTs, based on public single-cell data. (H) Dotplot showing the representative marker genes of each placenta cell type according to the public single-cell dataset (available at https://github.com/JustMoveOnnn/preeclampsia/tree/main/single_cell_matrix/data).