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. 2025 Oct 8;13:1659880. doi: 10.3389/fcell.2025.1659880

FIGURE 3.

A multi-panel scientific figure includes:A. UMAP visualization of cell types with a color-coded legend for various cell types like erythroblasts and fibroblasts.B and C. Enlarged sections labeled NC and PE with detailed cell distribution.D. Heatmap showing gene expression levels across different samples.E. Imaging of HLA-G/DAPI in NC and PE, indicative of cellular structures.F. Bar chart depicting percentage distribution of cell types.G. Differential interaction strength matrix among cell types.H and I. Network diagrams of THY1 and ncWNT signaling pathways for NC and PE.

Mapping of cell types to spatial locations in two placental samples. (A–C) Mapping of cell types to spatial locations with RCTD in two placental samples. (D) Heatmap showing the top 5 differentially expressed genes for each cell type. (E) Immunofluorescence staining of HLA-G in placental tissue sections from patients with preeclampsia and NC individuals. Red fluorescence indicates HLA-G expression, while blue fluorescence indicates DAPI nuclear staining. (F) Bar chart showing the proportions of different cell types in placental tissue sections from patients with preeclampsia and NC individuals. (G) Interaction heatmaps showing the differential interaction strengths among different cell types, including erythrocytes, EVTs, fibroblasts, macrophages, NK cells, SCTs, T cells, SMCs, VCTs, and pVCTs. (H,I) Interaction plots showing the ncWNT signaling pathway network and THY1 signaling pathway network among different cell types. EVTs: extravillous trophoblasts; NK cells: natural killer cells; SCTs: syncytiotrophoblasts; SMCs: smooth muscle cells; VCTs: cytotrophoblasts; pVCTs: proliferating cytotrophoblasts.