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. 2025 Oct 21;11:117. doi: 10.1038/s41540-025-00590-2

Fig. 7. Hill function modeling of target gene expression suggests variation in promoter affinity.

Fig. 7

A, B Surface plots comparing the fit of the model to experimental gene expression by root mean square error (RMSE) across a 200 × 200 parameter scan of mRNA decay rates (αm) between 0.02 and 1.4 h−1, and K values from 0.01–3 Cs. Minimum RMSE was used to calculate estimated decay rates and K values for each cluster, as shown in the table beneath each panel. C–E Comparison of the mass-action (red), Hill coefficient of 1.8 (magenta), and Hill coefficient of 4 (blue) models to experimental gene expression patterns (black) over time. F Computed root mean square error (RMSE) for each model as compared to each gene cluster.