Table 3.

CaSR NAM pK_B, logαβ and K_B values derived from Ca²⁺_i mobilization assays at both the wildtype and A840V variant.

Compound	WT			A840Va
	pKB	KB (nmol/L)	Logαβ (αβ)	pKB ± SEM (n)	KB (nmol/L)	Logαβ ± SEM (αβ)
NPS2143 (1)b	7.33	47	−1.73 (0.019)	6.76	174	−0.95 (0.112)
ATF936-NCS (4)	Refer to Table 1			6.65 ± 0.23 (4)	224	−2.40 ± 0.77 (0.004)

^aA840V data were best fitted with the comparative version of the operational model of cooperative agonism and allosterism (Eq. 2), whereas WT data (see Table 1) were fitted to the complete operational model of cooperative agonism and allosterism (Eq. 1). Analyses were performed on the collated data to derive the estimates of each parameter.

^bData for NPS2143 were previously reported^26,32, the best fit of the data using Eq. 2 are presented here to enable comparison.