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. 2025 Sep 28;14(9):3577–3588. doi: 10.21037/tlcr-2025-439

Table 3. Categorizing nodules into Lung-RADS 2022 based on size and nodule type.

Lung-RADS 2022 Malignant Benign
Solid Part solid Non-solid Solid Part solid Non-solid
2 (benign) 6 0 13 365 25 208
3 (probably benign) 8 19 0 253 50 0
4A (suspicious) 34 0* N/A 260 0* N/A
4B (very suspicious) 42 0* N/A 70 0* N/A

*, NLST did not incorporate measurement of solid component for part solid nodules, hence all part solid nodules ≥6 mm were classified as Lung-RADS 2022 criteria 3 for our analysis. Lung-RADS, Lung Imaging Reporting and Data System; N/A, not available; NLST, National Lung Screening Trial.