Table 2.
Cox proportional hazard models of CKD progression
| Variable | Model 0 (AIC 4063) |
Model 1 (AIC 4058) |
||||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P-value | Hazard ratio | 95% CI | P-value | |||
| Sex (female) | 1.07 | 0.87 | 1.32 | 0.51 | 1.05 | 0.85 | 1.30 | 0.65 |
| Age (yrs) | 1.06 | 1.02 | 1.09 | < 0.001 | 1.05 | 1.02 | 1.09 | < 0.001 |
| Glomerulopathies | 1.64 | 1.16 | 2.32 | 0.005 | 1.53 | 1.08 | 2.18 | 0.02 |
| log uPCR | 1.51 | 1.39 | 1.66 | < 0.001 | 1.50 | 1.37 | 1.64 | < 0.001 |
| Systolic BP SDS | 1.11 | 1.04 | 1.20 | 0.003 | 1.10 | 1.03 | 1.19 | 0.007 |
| log eGFR | 0.14 | 0.11 | 0.19 | < 0.001 | 0.17 | 0.12 | 0.23 | < 0.001 |
| log GDF-15 | - | - | - | - | 1.40 | 1.10 | 1.77 | 0.006 |
AIC, Akaike information criterion; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; GDF-15, growth differentiation factor 15; SDS, SD score; uPCR, urinary protein-to-creatinine ratio.
n = 667; reference for glomerulopathies: other diagnoses.