Table 5.

Cox proportional hazard models with stepwise inclusion of GDF-15 and uEGF in the 4C cohort

Variable	Model 0 (AIC 3069)				Model 1a (AIC 3062)
	Hazard ratio	95% CI		P	Hazard ratio	95% CI		P
Sex (female)	1.09	0.86	1.39	0.48	1.06	0.83	1.35	0.64
Age (yrs)	1.07	1.03	1.11	< 0.001	1.07	1.03	1.10	< 0.001
Glomerulopathies	1.73	1.16	2.59	0.01	1.56	1.03	2.34	0.03
log uPCR	1.55	1.40	1.71	< 0.001	1.53	1.38	1.69	< 0.001
Systolic BP SDS	1.13	1.03	1.24	0.01	1.12	1.02	1.22	0.02
log eGFR	0.22	0.16	0.31	< 0.001	0.27	0.18	0.38	< 0.001
log GDF-15	-	-	-	-	1.47	1.14	1.90	0.003
log uEGF/Cr	-	-	-	-	-	-	-	-

Variable	Model 1b (AIC 3053)				Model 2 (AIC 3051)
	Hazard ratio	95% CI		P	Hazard ratio	95% CI		P
Sex (female)	1.10	0.87	1.41	0.42	1.09	0.85	1.38	0.51
Age (yrs)	1.05	1.01	1.09	0.007	1.05	1.02	1.09	0.006
Glomerulopathies	1.61	1.08	2.42	0.02	1.49	0.99	2.26	0.06
log uPCR	1.72	1.53	1.93	<0.001	1.68	1.50	1.89	< 0.001
Systolic BP SDS	1.14	1.04	1.24	0.007	1.13	1.03	1.23	0.01
log eGFR	0.30	0.21	0.44	< 0.001	0.33	0.23	0.49	< 0.001
log GDF-15	-	-	-	-	1.31	1.01	1.71	0.05
log uEGF/Cr	0.81	0.74	0.89	< 0.001	0.83	0.75	0.91	< 0.001

AIC, Akaike information criterion; BP, blood pressure; CI, confidence interval; eGFR, estimated glomerular filtration rate; GDF-15, growth differentiation factor 15; SDS, SD score; uEGF/Cr, urinary epidermal growth factor / urinary creatinine; uPCR, urinary protein-to-creatinine ratio.

n = 536; reference for Glomerulopathies: other diagnoses.