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. 2025 Oct 9;12:1648334. doi: 10.3389/fmed.2025.1648334

Figure 1.

Correlation matrix using Spearman's rank correlation coefficient. Variables are cortisol, CCT, TCT, Kmax, BAD-D, IS-value, KI, PRFI, CBI, TBI, and SSI. Positive correlations are shown in red and negative in blue, with intensity indicating strength. The diagonal shows the strongest correlations, and circles with asterisks indicate statistical significance. A color bar on the right represents correlation values from -1 to 1.

Spearman correlation analysis between cortisol, the corneal morphological parameters, and corneal biomechanical parameters for all patients (CCT: central corneal thickness; TCT: thinnest corneal thickness; Kmax: maximum K value; BAD-D: Belin-Ambrosio Display D value; IS-value: inferior–superior value; KI: keratoconus index; PRFI: Pentacam random forest index; CBI: Corvis biomechanical index; TBI: tomographic and biomechanical index; SSI: stress–strain index; *, p < 0.05; **, p < 0.01; ***, p < 0.001).