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. 2025 Oct 22;15:36889. doi: 10.1038/s41598-025-20863-4

Table 1.

Summary of the clinical characteristics of the participants including demographics and concomitant medical conditions.

Population Demographics No. Of participants (%) p-value
Overall
(n = 64)
Survived
(n = 53)
Deceased
(n = 11)
Age (years) 66.4 ± 15.6 65.6 ± 14.9 70.6 ± 18.8 0.33
Age at diagnosis (years) 61.0 ± 16.0 59.5 ± 15.1 69.0 ± 19.2 0.09
Smoker 12 (18.8) 10 (18.9) 2 (18.2) 1.0
Male Gender 39 (60.9) 30 (56.6) 9 (81.8) 0.22
Ethnicity 0.08
Chinese 45 (70.3) 37 (69.8) 8 (72.7)
Malay 9 (14.1) 8 (15.1) 1 (9.1)
Indian 3 (4.7) 1 (1.9) 2 (18.2)
Others 7 (10.9) 7 (13.2) 0 (0.0)
Body Mass Index (kg/m2) 24.4 ± 6.0 24.6 ± 6.0 23.4 ± 5.8 0.58
Concomitant Medical Conditions
Cardiovascular Risk Factors
Hypertension 29 (45.3) 22 (41.5) 7 (63.6) 0.31
Hyperlipidaemia 25 (39.1) 18 (34.0) 7 (63.6) 0.14
Diabetes Mellitus 11 (17.2) 6 (11.3) 5 (45.5) 0.02
Peripheral Vascular Disease 1 (1.6, n = 63) 0 (0.0, n = 52) 1 (9.1) 0.39
Cardiac
Ischaemic Heart Disease 7 (10.9) 2 (3.8) 5 (45.5) < 0.001
Atrial Fibrillation 2 (3.1) 1 (1.9) 1 (9.1) 0.77
Congestive Cardiac Failure 1 (1.6) 0 (0.0) 1 (9.1) 0.38
Others
Stroke/Transient Ischaemic Attack 11 (17.2) 10 (18.9) 1 (9.1) 0.73
Hemiplegic 1 (1.6) 1 (1.9) 0 (0.0) 1.0
Chronic Kidney Disease 7 (10.9) 1 (1.9) 6 (54.5) < 0.001
Chronic Obstructive Pulmonary Disease 2 (3.1) 2 (3.8) 0 (0.0) 1.0
Malignancy 4 (6.2) 3 (5.7) 1 (9.1) 1.0
Dementia 1 (1.6) 1 (1.9) 0 (0.0) 1.0
Connective Tissue Disease 2 (3.1) 1 (1.9) 1 (9.1) 0.77
Outcomes
Deaths 11 (17.2) - - -
Major Adverse Cardiovascular Events (MACE) 10 (16.1, n = 62) 3 (5.7) 7 (77.8) < 0.001
Cardiovascular Death 5 (7.8) 0 (0.0) 5 (45.5) < 0.001
Congestive Cardiac Failure 4 (6.5, n = 62) 1 (1.9) 3 (33.3, n = 9) 0.005
Stroke 3 (4.8, n = 62) 1 (1.9) 2 (22.2, n = 9) 0.07
Acute Myocardial Infarction 4 (6.5, n = 62) 1 (1.9) 3 (33.3, n = 9) 0.005