Table II. Echocardiography of MEK5DD transgenic mice demonstrates eccentric hypertrophy and decreased fractional shortening.

	Non-transgenic	MEK5DD-TG	% change
6 weeks
IVSD	0.67 ± 0.01	0.66 ± 0.004	–1
IVSS	1.31 ± 0.01	1.04 ± 0.01	–21**
LVPWD	0.65 ± 0.01	0.60 ± 0.01	–5
LVPWS	1.08 ± 0.02	0.90 ± 0.01	–17
LVED	3.57 ± 0.03	4.47 ± 0.06	+28*
LVES	1.92 ± 0.02	3.39 ± 0.07	+76**
FS	0.46 ± 0.04	0.25 ± 0.06	–47**
10 weeks
IVSD	0.61 ± 0.004	0.57 ± 0.003	–4
IVSS	1.15 ± 0.01	0.91 ± 0.01	–21*
LVPWD	0.59 ± 0.01	0.54 ± 0.01	–5
LVPWS	1.08 ± 0.01	0.77 ± 0.01	–29**
LVED	3.85 ± 0.04	5.58 ± 0.08	+45**
LVES	2.31 ± 0.05	4.65 ± 0.09	+101**
FS	0.41 ± 0.06	0.17 ± 0.06	–58**

Measurements are given in millimeters, except fractional shortening (FS), which is unitless. Values were determined from three separate M-mode measurements and averaged between six mice in the non-transgenic group and 10 mice in the transgenic group.

Values are mean ± SEM; *P <0.05; **P <0.001.

IVSD, interventricular septum diastole; IVSS, interventricular septum systole; LVPWD, left ventricular posterior wall diastole; LVPWS, left ventricular posterior wall systole; LVED, left ventricular end diastolic dimension; LVES, left ventricular end systolic dimension.