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. 2025 Oct 9;10(41):48395–48411. doi: 10.1021/acsomega.5c05836

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© 2025 The Authors. Published by American Chemical Society

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(PR)₅₀ overexpression is linked to increases in acetylation on specific sites on Histones H3 and H4 in yeast. Representative blots showing increases in levels of (A) H3K9ac, (B) H3K14ac, (C) H3K27ac, and (D) H4K16ac in (PR)₅₀ yeast compared to controls. Column scatterplots quantify the relative density levels of histone PTMs in (PR)₅₀ yeast (blue) compared to loading controls (orange). Each point in the graph is a separate experiment with a different biological replicate. (n = 4–8), * = p ≤ 0.05.