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. 2025 Oct 9;10(41):48395–48411. doi: 10.1021/acsomega.5c05836

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© 2025 The Authors. Published by American Chemical Society

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Overexpression of (PR)₅₀ in yeast drives hyperphosphorylation of H3S10 through dysregulation of Ipl1. (PR)₅₀ polypeptides (black) are connected to both global increases in levels of H3S10ph and a growth suppression phenotype when overexpressed in yeast. Both effects can be modified by modulating Ipl1 (green), suggesting that (PR)₅₀’s toxicity is connected to epigenetic pathways. (PR)₅₀ possibly inhibits RanGAP, thus dysregulating nucleocytoplasmic export of Ipl1 or Glc7 (yellow). Created with BioRender.com.