Table 5.
Diagnostic performance of pupillary diameter cutoffs (4–8 mm) for predicting failure to achieve prehospital ROSC, stratified by pupillary light reflex (PLR) status.
| Analysis group | AUC | Cutoff | Specificity | FPR | Sensitivity |
|---|---|---|---|---|---|
| Overall (all patients) | 0.595 | ≥7 mm | 0.931 | 0.069 | 0.187 |
| ≥8 mm | 0.992 | 0.008 | 0.069 | ||
| PLR absent | 0.582 | ≥7 mm | 0.951 | 0.049 | 0.074 |
| ≥8 mm | 0.99 | 0.01 | 0.017 | ||
| PLR present | 0.669 | ≥7 mm | 0.961 | 0.039 | 0.044 |
| ≥8 mm | 1 | 0 | 0.004 |
ROSC = return of spontaneous circulation; AUC = area under the ROC curve; ROC = receiver operating characteristic; FPR (false positive rate) = 1 − specificity; PLR = pupillary light reflex.