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. 2025 Oct 24;23:581. doi: 10.1186/s12916-025-04405-3

Table 2.

Benchmark results as median RMSEbl.NLI and (2.5%-ile, 97.5%-ile) on held-out data for EMSCI and Sygen (external validation). The best-performing approach (lowest RMSEbl.NLI, if tied on median lower value for 97.5%-ile better) is highlighted. Columns labeled All times include all instances. Columns labeled 4 ± 1 weeks include instances with an initial assessment between 21 and 35 DAI

EMSCI Sygen
All times 4 ± 1 weeks All times 4 ± 1 weeks
Linear regression 0.63 (0.00, 2.22) 0.64 (0.02, 2.15) 0.70 (0.00, 2.32) 0.68 (0.08, 2.15)
Random forest 0.61 (0.01, 2.17) 0.60 (0.01, 2.08) 0.64 (0.03, 2.37) 0.61 (0.03, 1.89)
XGBoost 0.61 (0.01, 2.12) 0.61 (0.01, 2.08) 0.70 (0.01, 2.33) 0.68 (0.02, 2.00)
CNN 0.55 (0.00, 2.50) 0.55 (0.00, 2.57) 0.57 (0.00, 2.85) 0.60 (0.00, 2.90)
Transformer 0.63 (0.00, 2.58) 0.63 (0.00, 2.57) 0.65 (0.00, 3.00) 0.71 (0.00, 3.27)
GNN 0.58 (0.00, 2.60) 0.60 (0.00, 2.47) 0.68 (0.00, 2.61) 0.63 (0.00, 2.57)

Abbreviations: RMSEbl.NLI root mean squared error (RMSE) below neurological level of injury (bl.NLI), CNN convolutional neural network, GNN graph neural network