Table 2.
Summary of tumor findings from animal studies of vinyl acetate, with statistically significant findings in bold
| Species & strain System |
Rats | Mice | |||||
|---|---|---|---|---|---|---|---|
| SD [62] | SD derived Crl: CD(SD)BR [58, 60] | F344 [54, 55] | F344/DuCrj [56, 57] | Wistar [63] | Swiss [64] | Crj: BDF1 [56, 57] | |
| Respiratory |
Nasal cavity SCP (M)r, SCC (M r, F 2, r), carcinoma in situ (M)r, SCP, SCC and carcinoma in situ combined (M) r, Larynx SCC (F) r |
Pharynx carcinoma (M) 2 | Lung adenoma (F) 2 | Larynx SCC (M) r | |||
| Digestive |
Oral cavity and lips SCC (M, F), Tongue SCC (F) r, Forestomach SCC (M, F) r, Pancreatic Islet cell adenoma (M), Pancreatic exocrine adenoma (M) r |
Liver hepatocellular adenoma (F) |
Oral cavity and lips SCC (M, F) r, SCP (M) r, SCC and SCP combined (M) r |
Oral cavity and lips SCC (M, F), Tongue SCC (F), Esophagus SCC (M 2, F), Forestomach SCC (M, F) 2, Pancreatic exocrine adenoma (M) |
Oral cavity SCC (M, F), Tongue SCC (M 2, F), Esophagus SCC (M, F), Esophagus acanthoma (F) 2, Forestomach SCC (F), Forestomach acanthoma (M, F) |
Oral cavity and lips SCC (M, F) r, SCP (M, F) 2, r, SCC and SCP combined (M, F) r, Esophagus SCC (M) r, Forestomach SCC (M r, F2, r), SCP (M, F) r, SCC and SCP combined (M r, F 2, r) | |
| Endocrine | Adrenal gland pheochromo-blastoma (F) | Pituitary adenoma (F), Thyroid C-cell tumors (adenoma, adenoma and carcinoma combined) (F) | Thyroid C-cell tumors (adenoma, adenoma and carcinoma combined) (F) | Adrenal gland pheochromo-blastoma (M), pheochromo-cytoma (F) | |||
| Reproductive |
Uterine adenocarcinoma (F)r, Uterine endometrial stromal polyp (F) |
Testicular interstitial cell tumors (M) |
Uterine adenocarcinoma (F), Uterine fibrosarcoma (F) 2 |
Uterine leiomyosarcoma (F) | |||
| Immune | Lymphomas and leukemias of the hemolympho-reticular tissues (F) | Spleen malignant lymphoma (F) | |||||
| Auditory | Zymbal gland carcinoma (F) | ||||||
| Integumentary | Mammary gland adenocarcinoma (F) 2 | Mammary gland liposarcoma (F) 2 | |||||
r rare tumor, M Male, F Female, SCC Squamous cell carcinoma, SCP Squamous cell papilloma
1 The 104-week inhalation studies in male and female Crl:CD-1(ICR)BR mice [58, 61] did not identify any treatment-related tumors and are not included in this table
2 Tumor incidences with an apparent statistically significant trend, driven by increases (statistically non-significant) of tumors only at the high dose in comparison to controls. These findings are not in bold