Skip to main content
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1986 Jan;50(1):23–26.

Evaluation of a xylazine-ketamine hydrochloride combination in the cat.

D G Allen, D H Dyson, P J Pascoe, M R O'Grady
PMCID: PMC1255153  PMID: 3742353

Abstract

Cardiopulmonary function was assessed in healthy cats given a xylazine-ketamine hydrochloride combination intramuscularly. Cardiac output, heart rate, stroke volume and cardiac index were significantly decreased. Systolic, diastolic and mean arterial blood pressure were also significantly decreased. Systemic vascular resistance and central venous pressure were significantly increased. Blood gas values remained stable. In conclusion, significant cardiovascular depression was noted in normal cats given the xylazine-ketamine combination at the dosages listed.

Full text

PDF
23

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen D. G., Downey R. S. Echocardiographic assessment of cats anesthetized with xylazine-sodium pentobarbital. Can J Comp Med. 1983 Jul;47(3):281–283. [PMC free article] [PubMed] [Google Scholar]
  2. Allen D. G., Nymeyer D. A preliminary investigation on the use of thermodilution and echocardiography as an assessment of cardiac function in the cat. Can J Comp Med. 1983 Apr;47(2):112–117. [PMC free article] [PubMed] [Google Scholar]
  3. Arnbjerg J. Clinical manifestations of overdose of ketamine-xylazine in the cat. Nord Vet Med. 1979 Apr;31(4):155–161. [PubMed] [Google Scholar]
  4. Arnbjerg J. Klinisk anvendelse af ketamine-xylazine til bedøvelse af katte. Nord Vet Med. 1979 Apr;31(4):145–154. [PubMed] [Google Scholar]
  5. Cullen L. K., Jones R. S. Clinical observations on xylazine/ketamine anaesthesia in the cat. Vet Rec. 1977 Aug 6;101(6):115–116. doi: 10.1136/vr.101.6.115. [DOI] [PubMed] [Google Scholar]
  6. Klide A. M., Calderwood H. W., Soma L. R. Cardiopulmonary effects of xylazine in dogs. Am J Vet Res. 1975 Jul;36(7):931–935. [PubMed] [Google Scholar]
  7. Merin R. G. Effect of anesthetics on the heart. Surg Clin North Am. 1975 Aug;55(4):759–774. doi: 10.1016/s0039-6109(16)40679-1. [DOI] [PubMed] [Google Scholar]
  8. Mori K., Kawamata M., Mitani H., Yamazaki Y., Fujita M. A neurophysiologic study of ketamine anesthesia in the cat. Anesthesiology. 1971 Oct;35(4):373–383. doi: 10.1097/00000542-197110000-00012. [DOI] [PubMed] [Google Scholar]
  9. Moye R. J., Pailet A., Smith M. W., Jr Clinical use of xylazine in dogs and cats. Vet Med Small Anim Clin. 1973 Mar;68(3):236–passimassim. [PubMed] [Google Scholar]
  10. Muir W. W., Piper F. S. Effect of xylazine on indices of myocardial contractility in the dog. Am J Vet Res. 1977 Jul;38(7):931–934. [PubMed] [Google Scholar]
  11. Muir W. W., Skarda R. T., Milne D. W. Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses. Am J Vet Res. 1977 Feb;38(2):195–201. [PubMed] [Google Scholar]
  12. Newkirk H. L., Miles D. G. Xylazine as a sedative-analgesic for dogs and cats. Mod Vet Pract. 1974 Sep;55(9):677–passim. [PubMed] [Google Scholar]
  13. Pratila M. G., Pratilas V. Anesthetic agents and cardiac electromechanical activity. Anesthesiology. 1978 Nov;49(5):338–360. doi: 10.1097/00000542-197811000-00007. [DOI] [PubMed] [Google Scholar]
  14. Purohit R. C., Mysinger P. W., Redding R. W. Effects of xylazine and ketamine hydrochloride on the electroencephalogram and the electrocardiogram in the horse. Am J Vet Res. 1981 Apr;42(4):615–619. [PubMed] [Google Scholar]
  15. Stephenson J. C., Blevins D. I., Christie G. J. Safety of Rompun/Ketaset combination in dogs: a two-year study. Vet Med Small Anim Clin. 1978 Mar;73(3):303–306. [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES