Table 2. Transcription factors (TFs) implicated in hematopoietic reprogramming fall into four groups.

These range from TFs that are activated and bind chromatin in specific contexts (such as emergency myelopoiesis [EM] for CEBPB) to those that engage in widespread binding and play roles in dictating the global chromatin landscape (stripe factors). Check marks on the right indicate TF involvement within each study.

TF group	TF function specificity	Key members	Role in hematopoietic reprogramming	Models/Stimuli with evidence of TF group involvement
				Mouse				Human
				β-Glucan	BCG	LPS	Western diet	BCG	COVID
Lineage	+	C/EBP (β, α, ε, δ)	Required for cytokine-induced EM; downstream of G-CSF through STAT3	✓		✓		✓	✓
Cytokine responsive	+ +	STAT1, STAT3, STAT5	Mediates cytokine signaling (IL6, IFNs, G-CSF)		✓		✓	✓	✓
Ubiquitous pioneer	+ + +	FOS/JUN (AP-1)	Induced in many stimuli; drive enhancer formation and chromatin access			✓	✓	✓	✓
Universal stripe	+ + +	KLFs, SPs, EGRs, ZNFs	Enables through co-binding other TFs shaping epigenetic landscape				✓	✓	✓