Abstract
Mouse inoculation was used to test for the presence of a toxin in the serum, cerebrospinal fluid, and intestinal contents collected from cases of bovine enteric coccidiosis, with and without neurological signs, and from control calves. Intravenous inoculation of mice with 10 mL/kg of serum from calves showing nervous signs caused effects significantly different from those caused by the inoculation of serum from calves not showing nervous signs and from control calves. The effect was particularly evident in female mice. At this dosage severe neurological signs such as loss of righting reflex, seizures and death occurred only with serum from calves with "nervous coccidiosis". The results suggest that serum from the calves with neurological signs contains a neurotoxin. This toxin appears to be highly labile. It was not present in the cerebrospinal fluid at levels comparable to those in the serum. The significance of this labile neurotoxin with respect to the pathogenesis of the neurological signs associated with bovine enteric coccidiosis is unknown.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BERTKE E. M. RENAL FUNCTION DURING THE COURSE OF EIMERIA TENELLA INFECTION. J Parasitol. 1963 Dec;49:937–942. [PubMed] [Google Scholar]
- BURNS W. C. The lethal effect of Eimeria tenella extracts on rabbits. J Parasitol. 1959 Feb;45(1):38–46. [PubMed] [Google Scholar]
- Isler C. M., Bellamy J. E., Wobeser G. A. Pathogenesis of neurological signs associated with bovine enteric coccidiosis: a prospective study and review. Can J Vet Res. 1987 Apr;51(2):261–270. [PMC free article] [PubMed] [Google Scholar]
- Kogut M. H., Long P. L. Extraintestinal sporozoites of chicken Eimeria in chickens and turkeys. Z Parasitenkd. 1984;70(3):287–295. doi: 10.1007/BF00927814. [DOI] [PubMed] [Google Scholar]
- LEVINE L., HERRICK C. A. The effects of protozoan parasite Eimeria tenella on the ability of the chicken to do muscular work when its muscles are stimulated directly and indirectly. J Parasitol. 1954 Oct;40(5 Pt 1):525–531. [PubMed] [Google Scholar]
- Long P. L., Johnson J., Wyatt R. D. Pathological and clinical effects of Eimeria tenella in partially immune chickens. J Comp Pathol. 1981 Oct;91(4):581–587. doi: 10.1016/0021-9975(81)90087-6. [DOI] [PubMed] [Google Scholar]
- RIKIMARU M. T., GALYSH F. T., SHUMARD R. F. Some pharmacological aspects of a toxic substance from oocysts of the coccidium Eimeria tenella. J Parasitol. 1961 Jun;47:407–412. [PubMed] [Google Scholar]
- Ribi E., Anacker R. L., Brown R., Haskins W. T., Malmgren B., Milner K. C., Rudbach J. A. Reaction of endotoxin and surfactants. I. Physical and biological properties of endotoxin treated with sodium deoxycholate. J Bacteriol. 1966 Nov;92(5):1493–1509. doi: 10.1128/jb.92.5.1493-1509.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHUMARD R. F. Ovine coccidiosis; incidence, possible endotoxin, and treatment. J Am Vet Med Assoc. 1957 Dec 15;131(12):559–561. [PubMed] [Google Scholar]
- SHUMARD R. F. Studies on ovine coccidiosis. I. Some physiological changes taking place in experimental infections with Eimeria ninae-kohl-yakimovi (Yakimov and Rastegaeva, 1930) and Elmeria faurei (Moussu and Marotel, 1901). J Parasitol. 1957 Oct;43(5):548–554. [PubMed] [Google Scholar]
- Sénaud J., Vendrely R., Tronche P. Obtention, à partir d'un extrait de kystes de Sarcocystis tenella (Rail.), d'une fraction protéique toxique pour le lapin. C R Seances Soc Biol Fil. 1968;162(5):1184–1189. [PubMed] [Google Scholar]
- Sénaud J., Vendrely R., Tronche P. Sur la nature de la substance toxique des kystes de sarcosporidies du mouton (Toxoplasmea), active sur le lapin. C R Acad Sci Hebd Seances Acad Sci D. 1968 Mar 11;266(11):1137–1138. [PubMed] [Google Scholar]
- Van Heerden J. Muscular weakness in a dog associated with severe roundworm infestation. J S Afr Vet Assoc. 1983 Jun;54(2):133–134. [PubMed] [Google Scholar]