Table 1. The precision, accuracy, recovery and matrix effect of crizotinib and 2-Keto crizotinib in rat plasma (n = 5).
| Analytes | Concentration (ng/mL) |
Intra-Day | Inter-Day | Recovery (%) | Matrix effect (%) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Precision (RSD %) |
Accuracy (RE %) |
Precision (RSD %) |
Accuracy (RE %) |
Mean ± SD | RSD% | Mean ± SD | RSD% | ||
| Crizotinib | 2 | 7.7 | −3.2 | 8.0 | −4.5 | ||||
| 5 | 4.3 | −1.4 | 3.7 | −0.9 | 94.2 ± 5.3 | 5.6 | 93.3 ± 7.3 | 7.8 | |
| 120 | 1.8 | 1.7 | 1.8 | 0.3 | 100.5 ± 6.4 | 6.4 | 94.8 ± 5.1 | 5.3 | |
| 240 | 3.0 | −1.2 | 3.5 | −0.7 | 96.7 ± 3.2 | 3.3 | 100.2 ± 3.6 | 3.6 | |
| 2-Keto Crizotinib | 1 | 3.3 | 3.2 | 4.1 | 1.1 | ||||
| 2 | 2.8 | 2.2 | 3.0 | 1.0 | 92.5 ± 5.0 | 5.4 | 98.4 ± 5.1 | 5.2 | |
| 40 | 1.8 | −0.3 | 2.0 | −1.0 | 93.5 ± 2.3 | 2.5 | 102.7 ± 2.5 | 2.4 | |
| 80 | 2.8 | −3.1 | 2.3 | −3.1 | 92.9 ± 2.2 | 2.4 | 99.7 ± 3.0 | 3.0 | |