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| Protein concentration |
Activity (pmol cAMP/min) | |
|---|---|---|
| 4 µM | 45 nM | |
| K296A (C1) | 30 | |
| + D256A (C2) | 86 | |
| + D300A (C2) | 46 | |
| + D365A (C1) | 28 | |
| + R376A (C1) | 29 | |
| D365A (C1) | 0.2 | |
| + D256A (C2) | 3.6 | |
| + D300A (C2) | 0.7 | |
| + R376A (C1) | 1.7 | |
| D300A (C2) | 2.6 | |
| + D256A (C2) | 2.8 | |
The functional analogies to the C1 and C2 catalytic domains of mammalian ACs are in parentheses.
