Fig. 1. (A) Putative Man activation pathways and glycoconjugate biosynthesis in L.mexicana. The indication of GDP-Man and Dol-P-Man as Man donors for the biosynthesis of different Leishmania glycoconjugates is based on earlier studies (Ilgoutz et al., 1999). (B) Alignment of L.mexicana GDPMP (LmxGDPMP) with GDPMP amino acid sequences from various organisms: L.major (LmaGDPMP); A.thaliana (AthGDPMP); S.cerevisiae (ScerGDPMP; Hashimoto et al., 1997); H.sapiens (HsapGDPMP). Amino acids conserved in GDPMP of all five species are indicated by asterisks.