. 2025 Sep 27;28(11):113654. doi: 10.1016/j.isci.2025.113654

Table 2.

Effects of TRE on Weight loss and HOMA-IR in patients with PCOS

Variable	Changes from baseline (95% CIs)		Difference between groups (95% CIs)	p value
Variable	Control (n = 47)	TRE (n = 46)	Difference between groups (95% CIs)	p value
Weight, kg

Week 8	−2.69 (−4.26 to −1.12)^a	−5.85 (−7.34 to −4.37)^a	−3.16 (−5.32 to −1.00)	0.005
Week 16	−4.38 (−5.88 to −2.88)^a	−7.47 (−8.96 to −5.97)^a	−3.09 (−5.20 to −0.97)	0.005

HOMA-IR

Week 8	−1.47 (−2.05 to −0.90)^a	−1.63 (−2.16 to −1.10)^a	−0.16 (−0.94 to 0.62)	0.686
Week 16	−1.21 (−1.73 to −0.69)^a	−1.89 (−2.42 to −1.37)^a	−0.68 (−1.42 to 0.06)	0.071

Values are expressed as median (interquartile range).

TRE, Time-restricted eating; HOMA-IR, Homeostatic model assessment of insulin resistance.

p < 0.001 compared with baseline.