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Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1988 Jul;52(3):386–391.

Cardiopulmonary effects of a halothane/oxygen combination in healthy cats.

W Ingwersen 1, D G Allen 1, D H Dyson 1, P J Pascoe 1, M R O'Grady 1
PMCID: PMC1255469  PMID: 3139275

Abstract

The effects of a halothane/oxygen combination on the cardiopulmonary function of 11 healthy cats were studied. Test parameters included cardiac output, measured via thermo-dilution, heart rate, respiratory rate, arterial blood pressure (systolic, diastolic and mean) and blood gas analysis. Values for systemic vascular resistance, cardiac index and stroke volume were calculated from these data. Cardiac output, cardiac index, heart rate, stroke volume, arterial blood pressure (systolic, diastolic and mean) and arterial blood pH were significantly decreased (p less than 0.001). Respiratory rate was also significantly decreased (p less than 0.007) with arterial CO2 tension being significantly increased (p less than 0.001). Statistically significant changes, where seen, persisted for the duration of the anesthetic period. Arterial O2 tension and systemic vascular resistance remained unchanged. All parameters returned to near pretest values within 30 minutes following cessation of halothane anesthesia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen D. G., Dyson D. H., Pascoe P. J., O'Grady M. R. Evaluation of a xylazine-ketamine hydrochloride combination in the cat. Can J Vet Res. 1986 Jan;50(1):23–26. [PMC free article] [PubMed] [Google Scholar]
  2. Allen D. G., Nymeyer D. A preliminary investigation on the use of thermodilution and echocardiography as an assessment of cardiac function in the cat. Can J Comp Med. 1983 Apr;47(2):112–117. [PMC free article] [PubMed] [Google Scholar]
  3. Bahlman S. H., Eger E. I., 2nd, Halsey M. J., Stevens W. C., Shakespeare T. F., Smith N. T., Cromwell T. H., Fourcade H. The cardiovascular effects of halothane in man during spontaneous ventilation. Anesthesiology. 1972 May;36(5):494–502. doi: 10.1097/00000542-197205000-00017. [DOI] [PubMed] [Google Scholar]
  4. Corbett T. H. Pharmacology and toxicology of halogenated anesthetics. Adv Pharmacol Chemother. 1979;16:195–212. doi: 10.1016/s1054-3589(08)60245-8. [DOI] [PubMed] [Google Scholar]
  5. Cullen D. J., Eger E. I., 2nd Cardiovascular effects of carbon dioxide in man. Anesthesiology. 1974 Oct;41(4):345–349. doi: 10.1097/00000542-197410000-00006. [DOI] [PubMed] [Google Scholar]
  6. Duke P. C., Fownes D., Wade J. G. Halothane depresses baroreflex control of heart rate in man. Anesthesiology. 1977 Mar;46(3):184–187. doi: 10.1097/00000542-197703000-00005. [DOI] [PubMed] [Google Scholar]
  7. Dyson D. H., Allen D. G., McDonell W. N. Comparison of three methods for cardiac output determination in cats. Am J Vet Res. 1985 Dec;46(12):2546–2552. [PubMed] [Google Scholar]
  8. Dyson D. H., McDonnell W. N., Horne J. A. Accuracy of thermodilution measurement of cardiac output in low flows applicable to feline and small canine patients. Can J Comp Med. 1984 Oct;48(4):425–427. [PMC free article] [PubMed] [Google Scholar]
  9. Merin R. G. Inhalation anesthetics and myocardial metabolism: possible mechanisms of functional effects. Anesthesiology. 1973 Aug;39(2):216–255. doi: 10.1097/00000542-197308000-00012. [DOI] [PubMed] [Google Scholar]
  10. Merin R. G., Kumazawa T., Luka N. L. Myocardial function and metabolism in the conscious dog and during halothane anesthesia. Anesthesiology. 1976 May;44(5):402–415. doi: 10.1097/00000542-197605000-00009. [DOI] [PubMed] [Google Scholar]
  11. Muir W. W. Anesthesia and the heart. J Am Vet Med Assoc. 1977 Jul 1;171(1):92–98. [PubMed] [Google Scholar]
  12. Nadeau R. A., Colebatch H. J. Normal respiratory and circulatory values in the cat. J Appl Physiol. 1965 Sep;20(5):836–838. doi: 10.1152/jappl.1965.20.5.836. [DOI] [PubMed] [Google Scholar]
  13. Nishino T., Honda Y. Changes in the respiratory pattern induced by halothane in the cat. Br J Anaesth. 1980 Dec;52(12):1191–1197. doi: 10.1093/bja/52.12.1191. [DOI] [PubMed] [Google Scholar]
  14. Price H. L. Calcium reverses myocardial depression caused by halothane: site of action. Anesthesiology. 1974 Dec;41(6):576–579. doi: 10.1097/00000542-197412000-00008. [DOI] [PubMed] [Google Scholar]
  15. Price H. L., Skovsted P., Pauca A. L., Cooperman L. H. Evidence for beta-receptor activation produced by halothane in normal man. Anesthesiology. 1970 May;32(5):389–395. doi: 10.1097/00000542-197005000-00001. [DOI] [PubMed] [Google Scholar]
  16. Sonntag H., Donath U., Hillebrand W., Merin R. G., Radke J. Left ventricular function in conscious man and during halothane anesthesia. Anesthesiology. 1978 May;48(5):320–324. doi: 10.1097/00000542-197805000-00004. [DOI] [PubMed] [Google Scholar]
  17. Sonntag H., Merin R. G., Donath U., Radke J., Schenk H. D. Myocardial metabolism and oxygenation in man awake and during halothane anesthesia. Anesthesiology. 1979 Sep;51(3):204–210. doi: 10.1097/00000542-197909000-00005. [DOI] [PubMed] [Google Scholar]

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