Figure 6. GluR-B Expression in Hippocampus and Forebrain Partially Rescues the Memory Deficit of GluR-B^ΔFB Mice.

(A) Olfactory memory experiments as in Figure 2 were performed with GluR-B^Rescue. Individual mice are indicated: control GluR-B^2lox with black circles, GluR-B^ΔFB with red triangles, GluR-B^Rescue with green squares. Data were combined from Figure 3 and 4 (open symbols) and an additional experiment with four GluR-B^ΔFB, three littermate controls, and eight GluR-B^Rescue (shaded symbols).

(B) Cumulative histogram of the memory performance. Memory performance is indicated as a stepped line. The sigmoidal fit is indicated as a continuous line. The predicted rescue on the basis of the extent of transgenic ^GFPGluR-B expression (Figure 5D) and the correlation between memory and GluR-B levels in piriform cortex (9.1 ± 2.5% increase in memory for 10% increase in protein, Figure 4D) is shown in blue. Note that the predicted rescue is in perfect numerical correspondence to the memory performance of GluR-B^Rescue mice.

(C) The discrimination index was calculated as in Figures 1E, 2C, and 4D (last 100 trials of the mixture discrimination task) for GluRB^Rescue (n = 8), GluR-B^ΔFB (n = 22), and control (n = 14) animals.