Table 2.
Univariate and multivariate analysis of baseline risk factors for post-TIPS OHE (LT competing risk) in the pTIPS group (n=39).
| Univariate analysis for OHE in pTIPS group sHR [95% CI], p value |
p value | Multivariate analysis for OHE in pTIPS group sHR [95% CI], p value |
p value | |
|---|---|---|---|---|
| Age | 1.01 [0.98-1.05] | 0.32 | ||
| Type 2 diabetes | 2.18 [1.06-4.50] | 0.03 | 0.67 [0.15-2.93] | 0.6 |
| Previous OHE | 1.56 [0.76-3.22] | 0.23 | ||
| Previous cardiac disease | 2.16 [1.03-4.50] | 0.04 | 4.12 [1.21-14.1] | 0.02 |
| Sarcopenia | 2.91 [1.03-8.27] | 0.04 | 3.56 [1.27-9.96] | 0.016 |
| Baseline ammonia | 1.00 [0.99-1.01] | 0.74 | ||
| Platelets count | 1.00 [1.00-1.00] | 0.60 | ||
| Serum sodium | 1.00 [0.93-1.08] | 0.96 | ||
| Albumin | 0.97 [0.91-1.03] | 0.34 | ||
| Creatinine | 1.00 [1.00-1.01] | 0.11 | ||
| MELD score | 0.98 [0.93- 1.02] | 0.31 | ||
| Treatment with lactulose | 1.08 [0.55-2.12] | 0.82 | ||
| Large spontaneous shunts | 1.76 [0.89-3.47] | 0.06 | 1.72 [0.83-3.56] | 0.14 |
| PPG | 0.95 [0.81-1.11] | 0.52 |
Bolded values indicate statistically significant differences (p <0.05) (Fine and Gray models). MELD, model for end-stage liver disease; OHE, overt hepatic encephalopathy; PPG, portal pressure gradient; sHR, subdistribution hazard ratio.