Table 3.
Univariate and multivariate analysis of baseline risk factors for OHE (death and LT competing risk) in the elective TIPS group (n = 41).
| Univariate analysis for OHE in pTIPS group sHR [95% CI], p value |
p value | Multivariate analysis for OHE in pTIPS group sHR [95% CI], p value |
p value | |
|---|---|---|---|---|
| Age | 1.01 [0.97-1.05] | 0.52 | ||
| Type 2 diabetes | 1.74 [0.97-3.15] | 0.06 | ||
| Previous OHE | 0.63 [0.28-1.40] | 0.27 | ||
| Previous cardiac disease | 2.61 [1.41-4.82] | 0.001 | 2.39 [1.25-4.59] | 0.009 |
| Baseline ammonia | 1.01 [1.01-1.02] | <0.001 | 1.01 [1.00-1.02] | 0.022 |
| Sarcopenia | 0.82 [0.35-1.91] | 0.65 | ||
| Platelets count | 1.00 [1.00-1.00] | 0.28 | ||
| Serum sodium | 1.02 [0.96-1.08] | 0.56 | ||
| Albumin | 0.90 [0.85-0.96] | <0.001 | 0.93 [0.88-0.99] | 0.018 |
| Creatinine | 1.00 [1.00-1.01] | 0.66 | ||
| MELD score | 1.02 [0.95-1.10] | 0.52 | ||
| Treatment with rifaximin | 0.41 [0.21-0.79] | 0.008 | 0.62 [0.30-1.27] | 0.20 |
| Treatment with lactulose | 0.97 [0.49-1.90] | 0.92 | ||
| Large spontaneous shunts | 1.54 [0.79-3.02] | 0.21 | ||
| PPG | 1.01 [0.90-1.13] | 0.87 |
Bolded values indicate statistically significant differences (p <0.05) (Fine and Gray models). MELD, model for end-stage liver disease; OHE, overt hepatic encephalopathy; PPG, portal pressure gradient; sHR, subdistribution hazard ratio.