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. 2025 Oct 13;4:e63767. doi: 10.2196/63767

Table 6.

Results by model and outcome class for the model applied to different cancer sites.

Model, test dataset, and metrics Bio+ClinicalBERT Clinical-BigBird Clinical-Longformer

2-class 3-class 2-class 3-class 2-class 3-class

Head Tail Head and tail Head Tail Head and tail



Colorectal cancer model applied to breast cancer test dataset

Sensitivity, % 76.3 76.8 76.3 76.1 75.9 73.0 84.4 a 83.8 77.1 82.0

PPVb, % 83.9 85.1 81.6 78.3 87.0 83.3 81.4 83.3 87.0 82.7

AUCc 0.96 0.96 0.94 0.95 0.95 0.95 0.97 0.97 0.95 0.96

Scaled Brier score 0.62 0.63 0.61 0.58 0.65 0.60 0.65 0.68 0.69 0.66

Charts reduced, % 88.2 88.3 87.9 87.4 88.7 88.6 86.6 86.9 88.5 87.1
Breast cancer model applied to colorectal cancer test dataset

Sensitivity, % 69.4 63.4 75.4 70.7 63.0 70.3 68.5 83.6 86.8 82.4

PPV, % 80.6 82.5 76.3 80.9 82.9 77.7 86.8 74.6 70.8 74.0

AUC 0.97 0.96 0.97 0.97 0.96 0.97 0.97 0.98 0.98 0.98

Scaled Brier score 0.55 0.52 0.55 0.57 0.55 0.55 0.58 0.61 0.55 0.61

Charts reduced, % 90.8 91.8 89.5 90.7 91.9 90.4 91.2 88.1 86.9 88.1

aItalicization indicates the highest value.

bPPV: positive predictive value.

cAUC: area under the curve.