Table 5.
Distribution of Patients by Change in Visual Acuity (VA) of the Study Eye from Baseline to Examinations at Specified Times After Enrollment, SST Group H Trial
|
No. (%) of Patients by Time After Enrollment by Treatment Arm |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
3 mo |
6 mo |
12 mo |
24 mo |
36 mo |
||||||
| Change in | Observation (n = 99) | Surgery (n = 107) | Observation (n =99) | Surgery (n = 105) | Observation (n = 103) | Surgery (n = 106) | Observation (n = 97) | Surgery (n = 103) | Observation (n = 78) | Surgery (n = 90) |
| ≥4 Lines better | 6 (6) | 16 (15) | 8 (8) | 15 (14) | 4 (4) | 16 (15) | 10 (10) | 17 (17) | 8 (10) | 17 (19) |
| 2–3 Lines better | 12 (12) | 27 (25) | 14 (14) | 25 (24) | 13 (13) | 19 (18) | 11 (11) | 11 (11) | 8 (10) | 15 (17) |
| <2-Line change | 49 (49) | 35 (33) | 36 (36) | 34 (32) | 33 (32) | 34 (32) | 23 (24) | 27 (26) | 21 (27) | 16 (18) |
| 2–3 Lines worse | 22 (22) | 16 (15) | 23 (23) | 13 (12) | 17 (17) | 11 (10) | 14 (14) | 15 (15) | 11 (14) | 7 (8) |
| 4–5 Lines worse | 8 (8) | 4 (4) | 13 (13) | 6 (6) | 19 (18) | 9 (8) | 12 (12) | 13 (13) | 14 (18) | 16 (18) |
| ≥6 Lines worse | 2 (2) | 9 (8) | 5 (5) | 12 (11) | 17 (17) | 17 (16) | 27 (28) | 20 (19) | 16 (21) | 19 (21) |
| Median change, lines | −0.4 | + 0.8 | −0.6 | + 0.4 | −1.6 | −0.2 | −2.0 | −1.0 | −2.1 | −0.9 |
Abbreviation: SST, Submacular Surgery Trials.
*
One visual acuity line equals 5 letters. A fewer than 2-line change was defined as a visual acuity score no more than 7 letters (1.4 lines) worse or 7 letters better than baseline. Two to 3 lines better (or worse) was defined as a visual acuity score 8 letters (1.6 lines) to 17 letters (3.4 lines) better (or worse) than baseline.