Table 3.
Diagnostic Performance of Hypoxia, Oxidative Stress, and Ferroptosis-Related Indicators in Diagnosing Asthma Patients in a Healthy Population
| Variable | Cut-off Value | AUC (95% CI) | Sensitivity (%) | Specificity (%) | PLR | NLR | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|
| EOS (*10^9/L) | >0.075 | 0.935 | 0.867 | 0.950 | 17.333 | 0.056 | 0.963 | 0.826 |
| (0.865–1.000) | (0.745–0.988) | (0.854–1.000) | (2.533–117.702) | (0.351–0.963) | (0.892–1.034) | (0.671–0.981) | ||
| IL-4 (ng/mL) | >280.221 | 0.808 | 0.700 | 0.900 | 7.000 | 0.333 | 0.913 | 0.667 |
| (0.685–0.930) | (0.536–0.864) | (0.769–1.000) | (1.841–26.614) | (0.189–0.587) | (0.798–1.028) | (0.489–0.844) | ||
| IL-13 (ng/mL) | >16.675 | 0.966 | 0.933 | 0.900 | 9.333 | 0.074 | 0.933 | 0.900 |
| (0.923–1.000) | (0.844–1.000) | (0.769–1.000) | (2.498–34.879) | (0.019–0.285) | (0.844–1.023) | (0.769–1.031) | ||
| MDA (nmol/mL) | >3.576 | 0.933 | 0.867 | 1.000 | —— | 0.133 | 1.000 | 0.833 |
| (0.861–1.000) | (0.745–0.988) | (1.000–1.000) | —— | (0.054–0.332) | (1.000–1.000) | (0.863–0.982) | ||
| HIF-1α (pg/mL) | >347.055 | 0.736 | 0.733 | 0.650 | 2.095 | 0.410 | 0.759 | 0.619 |
| (0.598–0.874) | (0.575–0.892) | (0.441–0.859) | (1.110–3.954) | (00.209–0.806) | (0.603–0.914) | (0.411–0.827) | ||
| Nrf2 (ng/mL) | <117.374 | 0.876 | 0.750 | 0.967 | 22.500 | 0.259 | 0.938 | 0.853 |
| (0.761–0.990) | (0.560–0.940 | (0.902–1.000) | (3.222–157.136) | (0.121–0.554) | (0.819–1.056) | (0.734–0.972) | ||
| SOD (pg/mL) | <114.325 | 0.933 | 1.000 | 0.800 | 5.000 | 0.000 | 0.769 | 1.000 |
| (0.863–1.000) | (1.000–1.000) | (0.657–0.943) | (2.444–10.228) | —— | (0.607–0.931) | (1.000–1.000) | ||
| GPX4 | <0.045 | 0.786 | 0.700 | 0.833 | 4.200 | 0.360 | 0.737 | 0.806 |
| (0.651–0.921) | (0.499–0.901) | (0.700–0.967) | (1.795–9.827) | (0.181–0.717) | (0.539–0.935) | (0.667–0.946) |
Abbreviations: EOS, Eosinophils; IL-4, Interleukin 4; IL-13, Interleukin 13; MDA, Malondialdehyde; HIF-1α, Hypoxia-inducible factor 1 alpha; Nrf2, Nuclear factor erythroid 2-related factor 2; SOD, Superoxide dismutase; GPX4, Glutathione peroxidase 4; AUC, Area Under the Curve; PLR, Positive Likelihood Ratio; NLR, Negative Likelihood Ratio; PPV, Positive Predictive Value; NPV, Negative Predictive Value.