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. 2025 Sep 30;13(10):2403. doi: 10.3390/biomedicines13102403
ADMET Absorption, distribution, metabolism, excretion, and toxicity
AMPK AMP-activated protein kinase
ANOVA Analysis of variance
AUC Area under the curve
BBB Blood–brain barrier
CBF Cerebral blood flow
CMC Carboxymethyl cellulose
CNS Central nervous system
CYP Cytochrome pigment
DAPI 4′,6-Diamidino-2-phenylindole
EB Evans blue
eNOS endothelial NOS
FA Ferulic acid; 4-hydroxy-3-methoxycinnamic acid
FAD012 3,5-Dimethyl-4-hydroxy cinnamic acid
HO-1 Heme oxygenase-1
i.p. Intraperitoneal
i.v. Intravenous
LD50 Lethal dose 50
LOAEL Lowest observed adverse effect level
L-NAME NG-nitro-L-arginine methyl ester
MCAO/Re Middle cerebral artery occlusion following reperfusion
MMPs Matrix metalloproteinases
NO Nitric oxide
NOS NO synthase
Nrf2 Nuclear factor erythroid 2-related factor 2
PI3K phosphoinositide 3-kinase
t-PA Tissue plasminogen activator
TTC 2,3,5-Triphenyl tetrazolium chloride
PBS Phosphate-buffered saline
p-eNOS phosphorylated eNOS
RBMVECs Rat brain microvascular endothelial cells
ROS Reactive oxygen species
TJ Tight junction
vWF von Willebrand factor