Table II. Genotypes of offspring from heterozygous mating of type XIII collagen transgenic mice.
| Day of development | No. of litters | Total fetuses | Normal | Aborted | pb | ||
|---|---|---|---|---|---|---|---|
| |
|
|
Tg– (%) |
Tg+ (%) |
Tg+ (%) |
Resorbed (%)a |
|
| 9.5 | 5 | 46 | 14 (30.4) | 32 (69.6) | 0 | 0 | 0.3 |
| 10.5 | 10 | 79 | 22 (27.8) | 36 (45.6) | 18 (22.8) | 3 (3.8) | 0.002 |
| 11.5 | 14 | 96 | 25 (26.0) | 38 (39.6) | 13 (13.6) | 20 (20.8) | 0.00006 |
| 12.5 | 10 | 77 | 19 (24.6) | 29 (37.7) | 12 (15.6) | 17 (22.1) | 0.0001 |
| 13.5 | 10 | 80 | 27 (33.7) | 30 (37.5) | 9 (11.3) | 14 (17.5) | 0.00003 |
| 14.5–15.5 | 10 | 64 | 13 (20.3) | 26 (40.6) | 2 (3.1) | 23 (36.0) | 0.0001 |
| p >21 | 58 | 273 | 127 (46.5) | 146 (53.5) | 0 | 0 | 1.4 × 10–13 |
The genotype distributions of the offspring from heterozygous mating in transgenic lines 17, 23, 26 and 35 are pooled together in the table.
aA portion of the aborted fetuses could not be genotyped due to extensive resorption.
bThe p value was evaluated by the χ2 test for actual genotype segregation compared with the expected genotype segregation.