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. 2025 Oct 13;26(20):9948. doi: 10.3390/ijms26209948
MGB axis Microbiota–gut–brain axis
5-HT Serotonin
GABA Gamma-aminobutyric acid
DA Dopamine
CNS Central nervous system
HPA Hypothalamic–pituitary–adrenal
SCFAs Short-chain fatty acids
E1 Estrone
E2 17β-estradiol
E3 Estriol
PI3K phosphatidylinositol 3-kinase
Akt Protein kinase B
Bcl-2 anti-apoptotic protein
BDNF Brain-derived neurotrophic factor
IL-1β Interleukin-1β
IL-6 Interleukin-6
TNF-α Tumor necrosis factor alpha
SERT 5-HT transporter
SSRIs Selective serotonin reuptake inhibitors
NMDA N-metil-D-aspartate
AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
LTP Long-term potentiation
PSD-95 Postsynaptic density protein 95
MAPK Mitogen-Activated Protein Kinase
ERK Extracellular signal-regulated kinase
PMDD Premenstrual dysphoric disorder
MDD Major depressive disorder
NE Norepinephrine
BBB Blood–brain barrier
IFN-γ Interferon gamma
LPS Lipopolysaccharides
ZO-1 Tight junction proteins
SHBG Sex hormone-binding globulin
ERα Estrogen receptor alpha
ERβ Estrogen Receptor Beta
GH2 Glycoside hydrolase 2
gmGUS Intestinal microbial β-glucuronidase
OVX Ovariectomy
MAO Enzyme monoamine oxidase
KP Kynurenine pathway
IDO Enzyme indoleamine 2,3-dioxygenase
KYNA Kynurenic acid
QUIN Quinolinic acid
TPH2 Tryptophan hydroxylase-2
DRN Dorsal raphe nucleus
GPCR G-protein-coupled membrane receptors
NF-KB Nuclear factor kappa-light-chain-enhancer of activated B cells
TRP Tryptophan
3β-HSD 3β-hydroxysteroid dehydrogenase
3/17β-HSD 3/17β-hydroxysteroid dehydrogenase
CUMS Chronic unpredictable mild stress
CRP C-reactive protein
CUS Chronic unpredictable stress
NO Nitric oxide
MDA Malondialdehyde
GSH Glutathione
ACTH Adrenocorticotropic hormone
CORT Corticosterone
PCOS Polycystic ovary syndrome
PMS Premenstrual syndrome