Fig. 2. Lsm10 is a novel Sm-like protein. (A) Amino acid sequence of Lsm10. Peptides identified by mass spectrometry are underlined. Arrows indicate the region that was deleted in the Lsm10ΔPstI construct. The cDNA sequence was deposited in the DDBJ/EMBL/GenBank (accession No. AF394685). (B) Alignment of Lsm10 with human Sm D1 and D3 and the related Lsm2 and Lsm4 proteins across the Sm motifs 1 and 2. Highlighted Lsm10 residues are present in some (black) or all (grey) other proteins. The consensus sequence was adapted from previous sources (Hermann et al., 1995; Achsel et al., 1999). h, hydrophobic amino acids.