BBB	Blood–brain barrier
CaMKII	Calcium/calmodulin-dependent protein kinase II
CCI	Chronic constriction injury
CNS	Central nervous system
CNO	Clozapine-N-oxide
CREB	cAMP response element-binding protein
DL	Drug-likeness
DREADDs	Designer receptors exclusively activated by designer drugs
EIC	Extracted ion chromatogram
GABA	Gamma-aminobutyric acid
GO	Gene Ontology
HE	Hematoxylin–eosin staining
IPN	Interpeduncular nucleus
KEGG	Kyoto Encyclopedia of Genes and Genomes
MHb	Medial habenula
mPFC	Medial prefrontal cortex
NMDAR	N-methyl-D-aspartate receptor
NMDAR-2B	NMDA receptor subunit 2B
NPP	Neuropathic pain
OB	Oral bioavailability
OPA	Ortho-phthalaldehyde
RT-qPCR	Quantitative real-time PCR
SNI	Spared nerve injury
SNRIs	Serotonin–norepinephrine reuptake inhibitors
STZYD	Shentong Zhuyu Decoction
TCAs	Tricyclic antidepressants
TCM	Traditional Chinese medicine
TIC	Total ion chromatogram