Fig. 7. Model for fusion of endosome-derived vesicles with the late Golgi. The Ric1p–Rgp1p complex activates Ypt6p by nucleotide exchange at the late Golgi membrane. Ypt6p:GTP recruits the VFT complex, which also interacts with the N-terminal domain of Tlg1p on vesicles (and/or on the Golgi membrane). SNARE engagement and fusion follow. Sgm1p also binds Ypt6p and may provide an additional tethering function, though this remains to be shown.