Table 2. Univariate and multivariate Cox regression analysis of prognostic factors in overall survival of colorectal cancer patients.

Clinicopathological parameters	Cox univariate analysis			Cox multivariate analysis
	HR	95% CI	p	HR	95% CI	p
Sex (Male vs. Female)	0.945	0.521–1.713	0.851
Age (≥60 vs. <60)	1.702	0.921–3.146	0.090
Tumor diameter (≥7 cm vs. <7 cm)	0.853	0.412–1.765	0.668
T stage (T3 + T4 vs. T1 + T2)	1.203	0.473–3.063	0.698
N stage (N1-2 vs. N0)	3.021	1.646–5.547	<0.001	2.430	1.274–4.634	0.007
M stage (M1 vs. M0)	6.253	2.148–18.204	0.001	2.957	0.996–8.784	0.051
AJCC stage (III + IV vs. I + II)	3.185	1.712–5.928	<0.001
Vascular invasion (Yes vs. No)	2.257	0.808–6.304	0.120
Integrin β1 (High expression vs. Low expression)	3.899	2.091–7.271	<0.001	3.021	1.585–5.757	0.001

Note: HR, Hazard Ratio; CI, Confidence Interval; AJCC, American Joint Committee on Cancer.